Description
Adaptive Subgroup Selection in Group Sequential Trials.
Description
Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, <doi:10.1016/j.cct.2014.09.001>). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.
README.md
ASSISTant
ASSISTant is a package to assist in performing Adaptive Subgroup Selection In Sequential Trials.
ASSISTant provides a three-stage adaptive group sequential clinical trial design with provision for selecting a subgroup where the treatment may be effective. The package provides facilities for design, exploration and analysis of such trials using either continuous or discrete outcomes. A complete implementation of the initial design for the DEFUSE-3 trial is also provided as a vignette.