Description
Simultaneous Detection of Clusters and Cluster-Specific Genes in High-Throughput Transcriptome Data.
Description
Implements a new method 'ClussCluster' descried in Ge Jiang and Jun Li, "Simultaneous Detection of Clusters and Cluster-Specific Genes in High-throughput Transcriptome Data" (Unpublished). Simultaneously perform clustering analysis and signature gene selection on high-dimensional transcriptome data sets. To do so, 'ClussCluster' incorporates a Lasso-type regularization penalty term to the objective function of K- means so that cell-type-specific signature genes can be identified while clustering the cells.
README.md
ClussCluster
This package implements a new method ClussCluster to simultaneously perform clustering analysis and signature gene selection on high-dimensional transcriptome data sets. To do so, ClussCluster incorporates a Lasso-type regularization penalty term to the objective function of K-means so that cell-type-specific signature genes can be identified while clustering the cells.
Installing
To install this package and load it into R, do the following:
devtools::install_github("gabriellajg/ClussCluster")
library(ClussCluster)