Comparative Cohort Method with Large Scale Propensity and Outcome Models.

CohortMethod

CohortMethod is part of HADES.

Introduction

CohortMethod is an R package for performing new-user cohort studies in an observational database in the OMOP Common Data Model.

Features

• Extracts the necessary data from a database in OMOP Common Data Model format.
• Uses a large set of covariates for both the propensity and outcome model, including for example all drugs, diagnoses, procedures, as well as age, comorbidity indexes, etc.
• Large scale regularized regression to fit the propensity and outcome models.
• Includes function for trimming, stratifying, matching, and weighting on propensity scores.
• Includes diagnostic functions, including propensity score distribution plots and plots showing covariate balance before and after matching and/or trimming.
• Supported outcome models are (conditional) logistic regression, (conditional) Poisson regression, and (conditional) Cox regression.

Screenshots

Propensity (preference score) distribution	Covariate balance plot

Technology

CohortMethod is an R package, with some functions implemented in C++.

System Requirements

Requires R (version 4.0.0 or higher). Libraries used in CohortMethod require Java.

Installation

1. See the instructions here for configuring your R environment, including RTools and Java.

2. To install the latest stable version, install from CRAN:

   install.packages("CohortMethod")
   

3. Optionally, run this to check if CohortMethod was correctly installed:

   connectionDetails <- createConnectionDetails(dbms="postgresql",
                                                server="my_server.org",
                                                user = "joe",
                                                password = "super_secret")
   
   checkCmInstallation(connectionDetails)
   

   Where dbms, server, user, and password need to be changed to the settings for your database environment. Type

   ?createConnectionDetails
   

   for more details on how to configure your database connection.

User Documentation

Documentation can be found on the package website.

PDF versions of the documentation are also available:

• Vignette: Single studies using the CohortMethod package
• Vignette: Running multiple analyses at once using the CohortMethod package
• Package manual: CohortMethod.pdf

Support

• Developer questions/comments/feedback: OHDSI Forum
• We use the GitHub issue tracker for all bugs/issues/enhancements

Contributing

Read here how you can contribute to this package.

License

CohortMethod is licensed under Apache License 2.0

Development

CohortMethod is being developed in R Studio.

Development status

CohortMethod is actively being used in several studies and is ready for use.

Acknowledgements

• This project is supported in part through the National Science Foundation grant IIS 1251151.