Description
Dynamic Aggregation Testing.
Description
A multiple testing procedure aims to find the rare-variant association regions. When variants are rare, the single variant association test approach suffers from low power. To improve testing power, the procedure dynamically and hierarchically aggregates smaller genome regions to larger ones and performs multiple testing for disease associations with a controlled node-level false discovery rate. This method are members of the family of ancillary information assisted recursive testing introduced in Pura, Li, Chan and Xie (2021) <arXiv:1906.07757v2> and Li, Sung and Xie (2021) <arXiv:2103.11085v2>.
README.md
DYNATE
DYNATE package
Installation guidance
In R, run the following block of codes:
remotes::install_github(
repo = "jichunxie/DYNATE",
build_vignettes = TRUE,
build_manual = TRUE)
A tutorial of this package can be found in this repository under "DYNATE/vignettes/" or running the following block of codes in R:
library(DYNATE)
browseVignettes("DYNATE")