Description
Parameter Converter and Calculator for Health Technology Assessment.
Description
An interactive 'shiny' application for Health Technology Assessment (HTA) parameter estimation. Converts between rates, probabilities, odds, and hazard ratios (HR); extrapolates survival curves (Exponential, Weibull, Log-Logistic); fits probabilistic sensitivity analysis (PSA) distributions (Beta, Gamma, LogNormal, Dirichlet) via the method of moments; calculates incremental cost-effectiveness ratios (ICERs), net monetary benefit (NMB), value-based pricing, and budget impact; adjusts costs for inflation, discounting, and purchasing power parity (PPP) across 30 countries; and adjusts background mortality using life-table methods. Designed for researchers building cost-effectiveness and budget-impact models who need auditable, formula-documented parameter transformations. Methods include Zhang and Yu (1998) <doi:10.1001/jama.280.19.1690> for odds ratio (OR) to relative risk (RR) conversion and Chinn (2000, Statistics in Medicine, 19, 3127-3131) for effect-size transformations.
README.md
ParCC: Parameter Converter & Calculator for HTA
ParCC is an interactive Shiny application for Health Technology Assessment (HTA) parameter estimation. It bridges the gap between clinical evidence and economic models by automating complex parameter transformations with full formula documentation and literature citations.
Documentation:https://drpakhare.github.io/ParCC/
Installation
You can install ParCC from GitHub with:
# install.packages("remotes")
remotes::install_github("drpakhare/ParCC")
Quick Start
library(ParCC)
run_app()
Key Features
- Core Conversions -- Rate to Probability, Odds to Probability, Time Rescaling, OR to RR (Zhang & Yu), Effect Size (Chinn).
- HR Converter -- HR-to-probability, multi-HR comparison, NNT/NNH calculator, Log-rank to HR (Peto).
- Survival Extrapolation -- Exponential, Weibull, and Log-Logistic fitting from published KM data.
- Background Mortality -- SMR adjustment, Gompertz fitting, DEALE, linear interpolation.
- PSA Distributions -- Beta, Gamma, LogNormal (Method of Moments), Dirichlet (multinomial).
- Economic Evaluation -- ICER, Net Monetary Benefit, Value-Based Pricing (headroom analysis).
- Budget Impact Analysis -- 5-year BIA framework with population uptake curves and discounting (ISPOR).
- PPP Currency Converter -- Purchasing Power Parity conversion across 30 countries with WHO-CHOICE WTP thresholds.
- Global Currency Selector -- INR, USD, EUR, GBP, JPY, and more; all economic modules update automatically.
- Batch Processing -- Bulk rate, odds, and HR-based conversions with CSV upload/download.
- Lab Notebook -- Generates an HTML report with methodology and citations for every session.
What's New in v1.4.0
- Budget Impact Analysis (ISPOR framework)
- PPP Currency Converter with WHO-CHOICE WTP thresholds
- OR-RR and effect size conversions for NMA preparation
- NNT/NNH calculator and Log-rank to HR (Peto)
- Dirichlet distribution for Markov transition matrices
- Log-Logistic survival with non-monotonic hazard support
- Annuity / PV stream calculator
- Interactive clickable tool overview on Home page
- 5 new worked-example vignettes
Vignettes
After installation, browse the tutorials:
browseVignettes("ParCC")
Or visit the online documentation.
Citation
Regional Resource Centre for HTA, AIIMS Bhopal. (2025). ParCC: Parameter Converter & Calculator for Health Economic Evaluation (Version 1.4.0) [R package]. Available at: https://drpakhare.github.io/ParCC/