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Description

Simulate Non-Proportional Hazards.

A toolkit for simulation studies concerning time-to-event endpoints with non-proportional hazards. 'SimNPH' encompasses functions for simulating time-to-event data in various scenarios, simulating different trial designs like fixed-followup, event-driven, and group sequential designs. The package provides functions to calculate the true values of common summary statistics for the implemented scenarios and offers common analysis methods for time-to-event data. Helper functions for running simulations with the 'SimDesign' package and for aggregating and presenting the results are also included. Results of the conducted simulation study are available as preprint: "A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards", Klinglmueller et al. (2023) <doi:10.48550/ARXIV.2310.05622>.

SimNPH

Codecov test coverage CRAN status Lifecycle: stable

Simulate Non Proportional Hazards

This package provides several functions to simulate survival data with non proportional hazards using the general purpose simulation package SimDesign.

This package follows the structure of SimDesing and provides functions that can readily be used as generate, analyse and summarise arguments in SimDesign's runSimulation function.

Usage

Installation

The current development version can be installed with:

remotes::install_git("https://github.com/SimNPH/SimNPH.git")

Getting Started

Documentation for all functions can be found in the respective help topics in the package after installation or here

Some examples of data generation, testing and estimation can be found in this vignette.

Results of the Simulation Study

The results of the simulation study done by the CONFIRMS consortium in the course of the EMA tender will be published in an upcoming paper (preprint on arXiv) and are presented in a shinylive App.

Metadata

Version

0.5.5

License

Unknown

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