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Description

Cohort Platform Trial Simulation.

Cohort plAtform Trial Simulation whereby every cohort consists of two arms, control and experimental treatment. Endpoints are co-primary binary endpoints and decisions are made using either Bayesian or frequentist decision rules. Realistic trial trajectories are simulated and the operating characteristics of the designs are calculated.

cats

The goal of cats is to facilitate the simulation of cohort platform trials with either one short-term and one long-term binary endpoint (in the legacy branch) or two primary binary endpoints (master branch).

Installation

You can install the released version of Cats from CRAN using:

install.packages("cats")

And the development version from GitHub with:

# install.packages("devtools")
devtools::install_github("el-meyer/cats")

Usage

Please see the reference manual for more information on the usage of this package. The usage is nearly identical to that of the CohortPlat package by the same authors. A detailed vignette for that package’s usage can be found here.

Disclaimer

EU-PEARL (EU Patient-cEntric clinicAl tRial pLatforms) project has received funding from the Innovative Medicines Initiative (IMI) 2 Joint Undertaking (JU) under grant agreement No 853966. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA and Children’s Tumor Foundation, Global Alliance for TB Drug Development non-profit organization, Springworks Therapeutics Inc. This publication reflects the authors’ views. Neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein. The research of Elias Laurin Meyer was funded until 11/2020 by Novartis through the University and not at an individual level.

Metadata

Version

1.0.2

License

Unknown

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