Estimate Disease Severity and Case Ascertainment.

cfr: Estimate disease severity and under-reporting

cfr is an R package to estimate disease severity and under-reporting in real-time, accounting for delays in epidemic time-series.

cfr provides simple, fast methods to calculate the overall or static case fatality risk (CFR) of an outbreak up to a given time point, as well as how the CFR changes over the course of the outbreak. cfr can help estimate disease under-reporting in real-time, accounting for delays reporting the outcomes of cases.

cfr implements methods outlined in Nishiura et al. (2009). There are plans to add estimates based on other methods.

cfr is developed at the Centre for the Mathematical Modelling of Infectious Diseases at the London School of Hygiene and Tropical Medicine as part of the Epiverse-TRACE initiative.

Installation

cfr can be installed from CRAN using

install.packages("cfr")

The current development version of cfr can be installed from GitHub using the pak package.

if(!require("pak")) install.packages("pak")
pak::pak("epiverse-trace/cfr")

Quick start

Overall severity of the 1976 Ebola outbreak

This example shows how to use cfr to estimate the overall case fatality risks from the 1976 Ebola outbreak (Camacho et al. 2014), while correcting for delays using a Gamma-distributed onset to death duration taken from Barry et al. (2018), with a shape $k$ of 2.40 and a scale $\theta$ of 3.33.

# Load package
library(cfr)

# Load the Ebola 1976 data provided with the package
data(ebola1976)

# Calculate the static CFR without correcting for delays
cfr_static(data = ebola1976)
#>   severity_estimate severity_low severity_high
#> 1          0.955102    0.9210866     0.9773771

# Calculate the static CFR while correcting for delays
cfr_static(
  data = ebola1976,
  delay_density = function(x) dgamma(x, shape = 2.40, scale = 3.33)
)
#>   severity_estimate severity_low severity_high
#> 1            0.9742       0.8356        0.9877

Change in real-time estimates of overall severity during the 1976 Ebola outbreak

In this example we show how the estimate of overall severity can change as more data on cases and deaths over time becomes available, using the function cfr_rolling(). Because there is a delay from onset-to-death, a simple “naive” calculation that just divides deaths-to-date by cases-to-date will underestimate severity. The cfr_rolling() function uses the estimate_severity() adjustment internally to account for delays, and instead compares deaths-to-date with cases-with-known-outcome-to-date. The adjusted estimate converges to the naive estimate as the outbreak declines and a larger proportion of cases have known outcomes.

# Calculate the CFR without correcting for delays on each day of the outbreak
rolling_cfr_naive <- cfr_rolling(
  data = ebola1976
)

# see the first few rows
head(rolling_cfr_naive)
#>         date severity_estimate severity_low severity_high
#> 1 1976-08-25                 0            0         0.975
#> 2 1976-08-26                 0            0         0.975
#> 3 1976-08-27                 0            0         0.975
#> 4 1976-08-28                 0            0         0.975
#> 5 1976-08-29                 0            0         0.975
#> 6 1976-08-30                 0            0         0.975

# Calculate the rolling daily CFR while correcting for delays
rolling_cfr_corrected <- cfr_rolling(
  data = ebola1976,
  delay_density = function(x) dgamma(x, shape = 2.40, scale = 3.33)
)

head(rolling_cfr_corrected)
#>         date severity_estimate severity_low severity_high
#> 1 1976-08-25                NA           NA            NA
#> 2 1976-08-26             1e-04        1e-04        0.9999
#> 3 1976-08-27             1e-04        1e-04        0.9999
#> 4 1976-08-28             1e-04        1e-04        0.9999
#> 5 1976-08-29             1e-04        1e-04        0.9990
#> 6 1976-08-30             1e-04        1e-04        0.9942

We plot the rolling CFR to visualise how severity changes over time, using the ggplot2 package. The plotting code is hidden here.

# combine the data for plotting
rolling_cfr_naive$method <- "naive"
rolling_cfr_corrected$method <- "corrected"

data_cfr <- rbind(
  rolling_cfr_naive,
  rolling_cfr_corrected
)

Disease severity of ebola in the 1976 outbreak estimated on each day of the epidemic. The rolling CFR value converges to the static value towards the end of the outbreak. Both corrected and uncorrected estimates are shown.

Package vignettes

More details on how to use cfr can be found in the online documentation as package vignettes, under “Articles”.

Help

To report a bug please open an issue.

Contribute

Contributions to cfr are welcomed. Please follow the package contributing guide.

Code of conduct

Please note that the cfr project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.

Related projects

cfr functionality overlaps with that of some other packages, including

• coarseDataTools is an R package that allows estimation of relative case fatality risk between covariate groups while accounting for delays due to survival time, when numbers of deaths and recoveries over time are known. cfr uses simpler methods from Nishiura et al. (2009) that can be applied when only cases and deaths over time are known, generating estimates based on all data to date, as well as time-varying estimates. cfr can also convert estimates of cases with known outcomes over time into an estimate of under-ascertainment, if a baseline estimate of fatality risk is available from the literature (e.g. from past outbreaks).
• EpiNow2 is an R package that can allow estimation of case fatality risk if it is defined as a secondary observation of cases. In particular, it allows for estimation that accounts for the smooth underlying epidemic process, but this requires additional computational effort. A comparison of these methods is planned for a future release.

cfr is in future expected to benefit from the functionality of the forthcoming epiparameter package, which is also developed by Epiverse-TRACE. epiparameter aims to provide a library of epidemiological parameters to parameterise delay density functions, as well as the convenient <epidist> class to store, access, and pass these parameters for delay correction.

References