Description
Multi-Regime Marginal Structural Cox Model for Multi-Way Treatment Switching in Oncology Clinical Trials with Survival Endpoints
Description
Estimate the causal effect of sustained treatment strategies on overall survival in clinical trials with possible treatment crossover and switch to subsequent therapy. Simulate faithful longitudinal clinical trials data with survival endpoints and multi-way treatment switches allowing for time-dependent prognostic factors. For more on methodological background, please see: Keogh and colleagues (2021) <doi:10.1002/bimj.202000040> and Suarez and colleagues (2008) <doi:10.1016/j.jclinepi.2007.11.007>.