Description
Spectral Clustering-Based Method for Identifying B Cell Clones.
Description
Provides a computational framework for identification of B cell clones from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. Three main functions are included (identicalClones, hierarchicalClones, and spectralClones) that perform clustering among sequences of BCRs/IGs (B cell receptors/immunoglobulins) which share the same V gene, J gene and junction length. Nouri N and Kleinstein SH (2018) <doi: 10.1093/bioinformatics/bty235>. Nouri N and Kleinstein SH (2019) <doi: 10.1101/788620>. Gupta NT, et al. (2017) <doi: 10.4049/jimmunol.1601850>.
README.md
SCOPer
SCOPer provides a computational framework for the identification of B cell clonal relationships from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. It includes methods for assigning clonal identifiers using sequence identity, hierarchical clustering, and spectral clustering. SCOPer is part of the Immcantation analysis framework.
Contact
For help and questions please contact the Immcantation Group.