Description
Two-/Three-Stage Designs for Phase 1&2 Clinical Trials.
Description
Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.
README.md
tsdf
What is it?
tsdf calculates optimal Zhong's two-/three-stage Phase II designs, generates two-/three-stage Phase 1 dose finding decision table and allows user to run dose-finding simulations using customized decision table.
Installation
To install from CRAN:
install.packages("tsdf")
To install latest version from github :
install.packages("devtools")
devtools::install_github("wguo1990/tsdf")
References
[1] Bob Zhong, Single-arm phase IIA clinical trials with go/no-go decisions, 2012