Description
Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network.
Description
Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at <arXiv:1711.04702>.
README.md
wTO
wTO R package for Gene co-expression Network Analysis
To install it please use:
install.packages("devtools")
# Load the devtools package.
library(devtools)
install_github("deisygysi/wTO")
require(wTO)